NHG Health Investigator's Manual

About the NHG Health Investigator's Manual

The NHG Health Investigator's Manual is an amalgamation of the regulatory requirements, NHG Health DSRB research policies and institutional policies governing research conduct, allowing PIs to adeptly navigate the formidable convolutions of the research maze.

The latest Fifth Edition of the Investigator’s Manual includes the regulatory requirements (especially the revised regulatory framework for clinical trials), ethical provisions and institutional policies governing research conduct for Investigators, Researchers & Study Administrators.

Download the NHG Investigator Manual – All That an Investigator Needs to Know (5^th Edition) here.

Summary of Updates

• Summary of Change (November 2025)

Individual Chapters

Alternatively, you may choose to download the individual Chapters of the above NHG Health Investigator’s Manual which are of interest.

• Cover & Foreword

• Content Page

• Chapter 1 - Research Governance

• Chapter 2 - Regulation Requirements

• Chapter 3 - The Study Team

• [Updated] Chapter 4 - Submission to DSRB 

• Chapter 5 - Informed Consent

• Chapter 6 - Vulnerable Population

• [Updated] Chapter 7 - Study Conduct

• Chapter 8 - Standing Database

• Chapter 9 - Tissue Repository

• References and Suggested Readings

This Investigator Manual serves as guidance only and should be used in conjunction with, not as a substitute for, the official regulations and guidelines. Users must always consult and comply with current applicable regulations including ICH E6 (R3) Good Clinical Practice guidelines, local regulatory requirements (e.g., HPA/MA, HBRA), and institutional policies. In case of any discrepancy, official regulations and guidelines take precedence over this manual.