Unanticipated Problems Involving Risks to Subjects or Others (UPIRTSO)

Chicken Soup Series - UPIRTSO

• (Nov 2025) Identifying and Reporting UPIRTSO ↗ (opens in new tab)

• (Mar 2018) HBR Expected SAE ROAM Guide ↗ (opens in new tab)

_{DISCLAIMER: Past Issues/Articles may contain best practices, policies or SOPs that have been superseded or may no longer relevant or applicable. For NHG Health and partner institutions, we encourage you to refer to the latest NHG Health PCR SOPs (available via NHG Health Intranet access or Partner Institution’s CRU/Research office).  Always refer to your own institution’s latest policy, SOPs, guidance documents and templates.}